Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 3,170.00 | |
50 mg | 10-14 weeks | $ 4,180.00 | |
100 mg | 10-14 weeks | $ 5,800.00 |
Description | TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM). |
Targets&IC50 | RORγt, binding IC50:1.9 nM , RORγt, reporter gene IC50:6.1 nM |
In vivo | In mice with IL-23-induced cytokine expression model, TAK-828F (0.3, 1, and 3 mg/kg; orally administered; b.i.d.; 28 days; ) shows robust and dose-dependent inhibition of IL-17A expression with an ED80 of 0.5 mg/kg. |
Molecular Weight | 509.57 |
Formula | C28H32FN3O5 |
CAS No. | 1854901-94-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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TAK-828F 1854901-94-2 Metabolism ROR TAK 828F TAK828F inhibitor inhibit