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TC-DAPK 6

Catalog No. T17004 CAS 315694-89-4

TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.

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TC-DAPK 6, CAS 315694-89-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.
Targets&IC50	DAPK1:69 nM, DAPK3:225 nM
In vitro	TC-DAPK 6 inhibits p70S6K with IC50s of 1 μM-10 μM[1].

Molecular Weight	276.295
Formula	C17H12N2O2
CAS No.	315694-89-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 16.8 mg/mL (60.8 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Okamoto M, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TC-DAPK 6 315694-89-4 其他 Others TC DAPK 6 TCDAPK 6 Inhibitor inhibitor inhibit

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