Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 44.00 | |
2 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 413.00 | |
50 mg | In stock | $ 618.00 | |
100 mg | In stock | $ 879.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively. |
Targets&IC50 | human GPR39 without Zn2+:280 nM (EC50), murine GPR39 without Zn2+:180 nM (EC50), human GPR39 with Zn2+:9 nM (EC50), murine GPR39 with Zn2+:5 nM (EC50) |
In vitro | Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0)[1]. |
Molecular Weight | 397.79 |
Formula | C18H13ClFN7O |
CAS No. | 1144477-35-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.14 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TM-N1324 1144477-35-9 GPCR/G Protein Others GHSR TM N1324 Growth hormone secretagogue receptor TMN1324 TM-N-1324 TM-N 1324 Inhibitor inhibit inhibitor