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TMC353121

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TMC353121

Catalog No. T17107Cas No. 857066-90-1

TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, and IL-1β, as well as chemokines, KC, IP-10, MCP, and MIP1-α.

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Pack Size	Price	Availability	Quantity
2 mg	$137	In Stock

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Product Introduction

Bioactivity

Description	TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, and IL-1β, as well as chemokines, KC, IP-10, MCP, and MIP1-α.
In vitro	TMC353121 is an effective RSV fusion inhibitor, active against wild-type RSV (strain LO) with a 50% effective concentration (EC50) of 0.07 ng/mL in HeLaM cells[2].
In vivo	After single subcutaneous administration and repeated administration 24 hours post-intranasal RSV inoculation, TMC353121 dose-dependently reduces viral titers in bronchoalveolar lavage fluid[2].

Chemical Properties

Molecular Weight	558.71
Formula	C32H42N6O3
Cas No.	857066-90-1

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (53.70 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7898 mL	8.9492 mL	17.8984 mL	89.4919 mL
5 mM	0.3580 mL	1.7898 mL	3.5797 mL	17.8984 mL
10 mM	0.1790 mL	0.8949 mL	1.7898 mL	8.9492 mL
20 mM	0.0895 mL	0.4475 mL	0.8949 mL	4.4746 mL
50 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc