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Dersalazine
Catalog No. T70084Cas No. 188913-58-8
Alias Dersalazine Free Base
Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
Dersalazine
Catalog No. T70084Alias Dersalazine Free BaseCas No. 188913-58-8
Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $210 | In Stock | |
| 5 mg | $520 | In Stock | |
| 10 mg | $753 | In Stock | |
| 25 mg | $1,160 | In Stock | |
| 50 mg | $1,570 | In Stock | |
| 100 mg | $2,120 | In Stock | |
| 500 mg | $4,250 | In Stock |
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Purity:98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis. |
| In vivo | Dersalazine sodium (DS) (10 or 30 mg/kg; b.i.d.; rats), when administered for 7 days, showed intestinal anti-inflammatory effects in TNBS-induced colitis; these effects were observed both macroscopically and through the profile of inflammatory mediators (TNF, IL-1β, IL-6, and IL-17). Although the 2 day treatment with DS did not induce intestinal anti-inflammatory effects, it was sufficient to reduce the enhanced IL-17 expression. DS showed beneficial effects on DSS-induced colitis in C57BL/6 mice and reduced colonic pro-inflammatory cytokines IL-1β, IL-6, and IL-17.[2] |
| Alias | Dersalazine Free Base |
| Molecular Weight | 600.67 |
| Formula | C35H32N6O4 |
| Cas No. | 188913-58-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble）  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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