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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $472 | In Stock | |
2 mg | $662 | In Stock | |
5 mg | $993 | In Stock | |
10 mg | $1,330 | In Stock | |
25 mg | $1,980 | In Stock | |
50 mg | $2,680 | In Stock | |
100 mg | $3,620 | In Stock |
Description | Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling. Canakinumab has anti-inflammatory activity, inhibiting inflammation associated with autoimmune diseases by neutralizing IL-1β signaling.Canakinumab has been used for the treatment of gout and coronary artery disease. |
In vitro | Dose-dependently, Canakinumab (0-7 nM) represses IL-6 production in marmoset peripheral blood mononuclear cells, demonstrating IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively[2]. Effectively, Canakinumab competes with IL-1RI and IL-1RII for binding to IL-1b[2]. |
Alias | ACZ 885, Ilaris |
Cas No. | 914613-48-2 |
Storage | store at low temperature store at -20°C |
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