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Mesaconine

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COA

Mesaconine

Catalog No. TN1923Cas No. 6792-09-2

Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression.

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Pack Size	Price	Availability	Quantity
1 mg	$228	In Stock

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Product Introduction

Bioactivity

Description

In vitro

The anti-inflammatory effect of SFI was verified in vitro with endothelial cells. After detecting the cell viability, the expression of interleukin-6 (IL-6), inhibitor of nuclear factor kappa-B kinase (IKK), phosphorylated IKK, phosphorylated NF-κB and phosphorylated IκB-α± from the supernatant were determined. SFI could significantly suppress inflammatory responses, and the mechanism may be via an NF-κB-dependent pathway. Mesaconine is the first reported SFI compounds to have NF-κB inhibitor activity[1].

Chemical Properties

Molecular Weight	485.57
Formula	C24H39NO9
Cas No.	6792-09-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (113.27 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0594 mL	10.2972 mL	20.5944 mL	102.9718 mL
5 mM	0.4119 mL	2.0594 mL	4.1189 mL	20.5944 mL
10 mM	0.2059 mL	1.0297 mL	2.0594 mL	10.2972 mL
20 mM	0.1030 mL	0.5149 mL	1.0297 mL	5.1486 mL
50 mM	0.0412 mL	0.2059 mL	0.4119 mL	2.0594 mL
100 mM	0.0206 mL	0.1030 mL	0.2059 mL	1.0297 mL

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