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TR antagonist 1
🥰Excellent
Catalog No. T13435Cas No. 500794-88-7
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
TR antagonist 1
🥰Excellent
Purity: 99.57%
Catalog No. T13435Cas No. 500794-88-7
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $299 | In Stock |
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Purity:99.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities. |
| Targets&IC50 | Thyroid hormone β:22 nM, THRα:36 nM |
| In vitro | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50 s of 36 and 22 nM for TRα and TRβ, respectively[1]. |
| In vivo | In the cholesterol-fed rat model, treatment with TR antagonist 1 reduces heart rate and shows a tendency to increase the proportion of low-density lipoprotein cholesterol (LDL-C) to a certain extent [1]. |
| Molecular Weight | 561.26 |
| Formula | C25H23Br2NO4 |
| Cas No. | 500794-88-7 |
| Smiles | CC(C)c1cc(Oc2c(Br)cc(CCC(O)=O)cc2Br)cc(\C=C\c2ccncc2)c1O |
| Relative Density. | 1.553 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (89.13 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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