Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.

Taiwanin C (1-60μM,24h) demonstrated a dose-dependent inhibition of cell viability specifically in T28 cells, while it had no impact on the normal N28 cells. Treatment with Taiwanin C dose-dependently suppressed the migration ability of T28 cells, as assessed by wound healing and migration assays. Additionally, Taiwanin C decreased the levels of β-catenin, as well as its downstream metastatic proteins Tbx3 and cMyc. Furthermore, Taiwanin C hindered the nuclear accumulation of β-catenin and facilitated its degradation through a pathway involving proteasomes. Moreover, Taiwanin C enhanced the activity of GSK-3β and reduced the levels of phosphorylated (p-ser9) GSK-3β, thereby inactivating the Wnt signaling pathway. In summary, Taiwanin C impeded the cell migration effects of T28 cells by activating GSK-3β, which led to enhanced protein degradation and reduced nuclear accumulation of β-catenin.[1]

Taiwanin C (20 mg/kg/d, 30 mg/kg/d, 15d; injected) showed effective anti_x0002_tumor activity in nude mice models.[1]