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Thioperamide maleate

Name: Thioperamide maleate
Brand: TargetMol
SKU: T41247
Price: -1 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41247Cas No. 148440-81-7

Alias MR-12842 maleate

Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM).

Thioperamide maleate

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Purity: 99.88%

Catalog No. T41247Alias MR-12842 maleateCas No. 148440-81-7

Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM).

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$129	In Stock
25 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock

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Purity:99.88%

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COA HPLC HNMR

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Product Introduction

Bioactivity

Description	Thioperamide maleate (MR-12842 maleate) is an effective and selective H3 receptor antagonist (Ki = 4.3 nM) that inhibits [3H]histamine synthesis (Ki = 31 nM).
Targets&IC50	[3H]-Histamine synthesis:31 nM(Ki), H3 receptor:4.3 nM(Ki)
In vitro	Thioperamide maleate (0.01, 0.1, 1, 10, 100 μM) promotes the viability of NE-4C stem cells in a concentration-dependent manner[1]. Thioperamide maleate displays similar potencies at human H4 and H3 receptors with Kis of 43 and 60 nM, respectively[2]. Thioperamide maleate inhibits [3H]-(R)α-MeHA binding rat brain and guinea-pig lung with Kis of 2.1 nM and 2.0 nM, respectively. Thioperamide maleate competitively blocks H3-autoreceptors regulating [3H]histamine release with a mean apparent Ki of 4 nM[4].
In vivo	In C57BL/6J mice, Thioperamide (5-20 mg/kg; i.p.) facilitates reconsolidation of a contextually-conditioned fear memory[3].
Alias	MR-12842 maleate

Chemical Properties

Molecular Weight	408.52
Formula	C₁₉H₂₈N₄O₄S
Cas No.	148440-81-7
Smiles	OC(=O)\C=C/C(O)=O.S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (134.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4479 mL	12.2393 mL	24.4786 mL	122.3930 mL
5 mM	0.4896 mL	2.4479 mL	4.8957 mL	24.4786 mL
10 mM	0.2448 mL	1.2239 mL	2.4479 mL	12.2393 mL
20 mM	0.1224 mL	0.6120 mL	1.2239 mL	6.1197 mL
50 mM	0.0490 mL	0.2448 mL	0.4896 mL	2.4479 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc