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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $113 | In Stock | |
25 mg | $239 | In Stock | |
50 mg | $343 | In Stock | |
100 mg | $515 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both. |
Targets&IC50 | mTORC1(MDAMB231):6 μM, mTORC1(BT474 cells):2.5 μM |
Alias | Filiferin B, AneMarsaponin A3, Timosaponin A3 |
Molecular Weight | 740.92 |
Formula | C39H64O13 |
Cas No. | 41059-79-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (67.48 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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