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VBIT-4

Catalog No. T13287 CAS 2086257-77-2

VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).

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VBIT-4, CAS 2086257-77-2

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Purity: 98%

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Description	VBIT-4 is a voltage-dependent anion channel 1 (VDAC1) oligomerization inhibitor (Kd: 17 μM). VBIT-4 can be used for therapeutic purposes in apoptosis-associated disorders (such as neurodegenerative and cardiovascular diseases).
Targets&IC50	VDAC1:(kd)17 μM
In vitro	VBIT-4 targets the mitochondrial protein VDAC1, inhibits apoptosis and defends against mitochondrial dysfunction.?VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells , IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively).VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.

Molecular Weight	457.87
Formula	C21H23ClF3N3O3
CAS No.	2086257-77-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (273.00 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Bioactive Compound Library

Related Products

Related compounds with same targets

VBIT-12 NSC 15364 DIDS sodium salt Erastin VBIT-4

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Keywords

VBIT-4 2086257-77-2 Membrane transporter/Ion channel VDAC VBIT4 VBIT 4 Inhibitor inhibitor inhibit

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