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VER49009
Catalog No. T2268Cas No. 940289-57-6
Alias VER-49009, VER 49009, CCT0129397
VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
VER49009
Catalog No. T2268Alias VER-49009, VER 49009, CCT0129397Cas No. 940289-57-6
VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $55 | In Stock | |
| 2 mg | $77 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $176 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $677 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM). |
| Targets&IC50 | HSP90:25 nM |
| In vitro | In the human ovarian tumor model, intraperitoneal injection of VER-49009 (4 mg/kg) can induce the dissociation of HSP90 and ERBB2. In athymic mice, intravenous injection of VER-49009 (20 mg/kg) demonstrates efficacy. |
| In vivo | VER-49009 can induce the dissociation of HSP72 and HSP27 from their binding proteins, leading to cell cycle arrest. In recombinant yeast Hsp90 protein (IC50 = 167 nM), VER-49009 inhibits the endogenous ATPase activity. During the treatment of liver fibrosis, VER-49009 induces the accumulation of hepatic stellate cells (CFSC) in the G2 phase, inhibiting cell growth. |
| Kinase Assay | Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe. |
| Cell Research | Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference) |
| Alias | VER-49009, VER 49009, CCT0129397 |
| Molecular Weight | 387.82 |
| Formula | C19H18ClN3O4 |
| Cas No. | 940289-57-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 71 mg/mL (183.1 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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