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Yoda 1

Catalog No. T7506 CAS 448947-81-7

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)

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Yoda 1, CAS 448947-81-7

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)
Targets&IC50	Piezo1-transfected HEK293T cells:17.1 μM , human Piezo1-transfected HEK293T cells:26.6 μM
In vitro	Yoda1 that acts as an agonist for both human and mouse Piezo1.?Functional studies in cells revealed that Yoda1 affects the sensitivity and the inactivation kinetics of mechanically induced responses[1].

Molecular Weight	355.26
Formula	C13H8Cl2N4S2
CAS No.	448947-81-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL (95.70 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ruhma S , Jie X , Dubin A E , et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife, 2015, 4. 2. Davies JE, Lopresto D, Apta BHR,et al.Using Yoda-1 to mimic laminar flow in vitro: A tool to simplify drug testing[J].Biochem Pharmacol. 2019 Oct;168:473-480.

Citations

1. Zheng Q, Zou Y, Teng P, et al. Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells. Cells. 2022, 11(14): 2191 2. Chen L, Yan Y, Kong F, et al. Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells. Cancers. 2022, 14(8): 2036

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Yoda 1 448947-81-7 其他 Others KcsA Potassium Channel Akt Yoda-1 PKB Inhibitor A431 cells HCAECs inhibit Protein kinase B ERK Piezo1 Extracellular signal regulated kinases Endothelial cells ERK1/2 Piezo Channel Yoda1 inhibitor

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