Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $45 | In Stock | |
10 mg | $71 | In Stock | |
25 mg | $157 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $457 | In Stock | |
500 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $49 | In Stock |
Description | Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively. |
Targets&IC50 | HCN3:1.90 µM, HCN4:1.88 µM, HCN1:1.83 µm, HCN2:2.21 µM, HCN:1.96 μM |
In vitro | Zatebradine demonstrates a use-dependent inhibitory effect on the cardiac pacemaker current in rabbit sino-atrial node cells, with an observed Kd value of 480 nM.[2] |
In vivo | Zatebradine hydrochloride (0-20 mg/kg; i.p.; for 30 minutes; male C57/Bl6-mice) decreases the heart rate dose-dependently from 600 to 200 bpm (ED50: 1.8 mg/kg).[1] |
Alias | UL-FS-49CL, UL-FS-49 |
Molecular Weight | 493.04 |
Formula | C26H37ClN2O5 |
Cas No. | 91940-87-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (182.5 mM), Sonication is recommended. H2O: 90.0 mg/mL (182.5 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.