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Zatebradine
Catalog No. T13387Cas No. 85175-67-3
Alias UL-FS-49CL free base, UL-FS-49 free base
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
Zatebradine
Catalog No. T13387Alias UL-FS-49CL free base, UL-FS-49 free baseCas No. 85175-67-3
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $88 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM). |
| Targets&IC50 | HCN:1.96 µM |
| In vitro | Zatebradine exhibits a use-dependent blockade of the cardiac pacemaker current in rabbit sino-atrial node cells (Kd 480 nM) [2]. |
| In vivo | In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1]. |
| Alias | UL-FS-49CL free base, UL-FS-49 free base |
| Molecular Weight | 456.57 |
| Formula | C26H36N2O5 |
| Cas No. | 85175-67-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (109.51 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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