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[Pyr1]-Apelin-13

Catalog No. TP1260 CAS 217082-60-5

Synonyms: [pGlu1]-Apelin-13

[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.

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[Pyr1]-Apelin-13, CAS 217082-60-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.
In vitro	[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release both in vitro and in vivo[1].
In vivo	[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold than SCI animals from the second week post SCI[2].

Synonyms	[pGlu1]-Apelin-13
Molecular Weight	1533.8
Formula	C69H108N22O16S
CAS No.	217082-60-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 50 mg/mL (32.60 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

[Pyr1]-Apelin-13 217082-60-5 GPCR/G Protein Apelin receptor inhibit [Pyr1]Apelin13 [pGlu1]-Apelin-13 [Pyr1] Apelin 13 Inhibitor [Pyr-1]-Apelin-13 inhibitor

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