Powder: -20°C for 3 years | In solvent: -80°C for 1 year
[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 736.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,360.00 |
Description | [Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist. |
In vitro | [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release both in vitro and in vivo[1]. |
In vivo | In a study involving a mouse model of pressure-overload induced heart failure, nanocarriers containing [Pyr1]-apelin-13 demonstrated a prolonged effect in preventing cardiac dysfunction, highlighting its potential therapeutic benefits. Additionally, [Pyr1] apelin-13 at doses of 1 and 5 μg was found to enhance locomotor activity, alleviate pain symptoms, decrease cavity size, and reduce caspase-3 levels in rats, indicating its analgesic and anti-inflammatory properties. Furthermore, the compound significantly increased thermal paw withdrawal latency and, at a 5 μg dose, notably improved paw withdrawal threshold in comparison to spinal cord injury (SCI) animals from the second week post-SCI, suggesting its effectiveness in pain management and functional recovery post-SCI. |
Synonyms | [pGlu1]-Apelin-13 |
Molecular Weight | 1533.8 |
Formula | C69H108N22O16S |
CAS No. | 217082-60-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (32.60 mM)
You can also refer to dose conversion for different animals. More
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[Pyr1]-Apelin-13 217082-60-5 GPCR/G Protein Apelin receptor inhibit [Pyr1]Apelin13 [pGlu1]-Apelin-13 [Pyr1] Apelin 13 Inhibitor [Pyr-1]-Apelin-13 inhibitor