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ELA-14(human) acetate
🥰Excellent
Catalog No. TP1923L1
Alias ELA-14(human) acetate (1886973-05-2 free base)
ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
ELA-14(human) acetate
🥰Excellent
Purity: 97.20%
Catalog No. TP1923L1Alias ELA-14(human) acetate (1886973-05-2 free base)
ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $320 | In Stock | |
| 25 mg | $518 | In Stock | |
| 50 mg | $713 | In Stock | |
| 100 mg | $948 | In Stock | |
| 200 mg | $1,270 | In Stock |
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Purity:97.20%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide. |
| Targets&IC50 | β-arrestin2:166 nM(EC50), Gαi1:8.6 nM(EC50) |
| In vitro | ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1]. |
| In vivo | ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1]. |
| Alias | ELA-14(human) acetate (1886973-05-2 free base) |
| Molecular Weight | 1767.09 |
| Formula | C77H123N25O19S2 |
| Smiles | CC(C)C[C@@H](C(N[C@@H](Cc1c[nH]cn1)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N(CCC1)[C@@H]1C(N[C@@H](Cc1ccccc1)C(N(CCC1)[C@@H]1C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC1)N1C([C@H](CCSC)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC1)NC1=O)=O)=O)=O)=O)=O)=O.CC(O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/ml (56.59 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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