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TRV-120027 TFA

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Purity:97.45%

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COA LCMS

TRV-120027 TFA

Catalog No. TP2158

TRV-120027 TFA is an angiotensin II–mediated vasoconstriction inhibitor and increases cardiomyocyte contractility. TRV-120027 TFA is a β-arrestin-1-biased AT1R agonist engaging ß-arrestins while blocking G-protein signaling[1]. TRV-120027 TFA induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane.

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Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$198	In Stock
10 mg	$315	In Stock
25 mg	$542	In Stock
50 mg	$782	In Stock
100 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$359	In Stock

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Product Introduction

Bioactivity

Description	TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.
Targets&IC50	Ang II type 1 receptor:
In vitro	Treatment of 100 nM TRV-120027 TFA induces an [Ca2+]i increase in HEK293 cells co-transfected with AT1R, β-arrestin-1, and TRPC3, which are significantly blocked by Pyr3 pre-incubation in HEK293 cells co-transfected with Flag-AT1R-Cherry, HA-β-arrestin-1, and TRPC3-GFP[1]. Treatment of 100 nM TRV-120027 TFA significantly increases the AT1R and TRPC3 association with the immunoprecipitated β-arrestin-1 in HEK293 cells co-transfected with Flag-AT1R-cherry, HA-β-arrestin-1 and TRPC3-GFP[1].
In vivo	TRV-120027 TFA combined with furosemide decreases cardiac preload and afterload, systemic and renal vascular resistances, and left ventricular external work while increasing cardiac output and renal blood flow[2].
Alias	TRV-120027 TFA (1234510-46-3 free base)

Chemical Properties

Molecular Weight	1040.1
Formula	C45H68F3N13O12
Cas No.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 88 mg/mL (84.61 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9614 mL	4.8072 mL	9.6145 mL	48.0723 mL
5 mM	0.1923 mL	0.9614 mL	1.9229 mL	9.6145 mL
10 mM	0.0961 mL	0.4807 mL	0.9614 mL	4.8072 mL
20 mM	0.0481 mL	0.2404 mL	0.4807 mL	2.4036 mL
50 mM	0.0192 mL	0.0961 mL	0.1923 mL	0.9614 mL

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