GAT211

GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.

Catalog No. T27405Cas No. 102704-40-5

Select Batch

Purity:99.7%

Resource Download

COA HNMR HPLC

GAT211

Catalog No. T27405Cas No. 102704-40-5

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$97	In Stock
25 mg	$159	In Stock
50 mg	$233	In Stock
100 mg	$345	In Stock
500 mg	$833	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "GAT211"

Product Introduction

Bioactivity

Description	GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
In vitro	GAT211 limits dopamine D2 receptor-mediated extracellular signal-regulated kinase (ERK) phosphorylation in Neuro2a cells, while THC does not[2].
In vivo	When administered alone, GAT211 treatment (0.3-3.0 mg/kg) dose-dependently reduces locomotor activity and acoustic startle response. GAT211 (3.0 mg/kg) also prevents MK-801-induced hyperlocomotion but has no significant effect on PPI impairment[2].
Alias	AZ4, GAT-211, AZ 4, GAT 211, AZ-4

Chemical Properties

Molecular Weight	342.39
Formula	C₂₂H₁₈N₂O₂
Cas No.	102704-40-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (233.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9206 mL	14.6032 mL	29.2065 mL	146.0323 mL
5 mM	0.5841 mL	2.9206 mL	5.8413 mL	29.2065 mL
10 mM	0.2921 mL	1.4603 mL	2.9206 mL	14.6032 mL
20 mM	0.1460 mL	0.7302 mL	1.4603 mL	7.3016 mL
50 mM	0.0584 mL	0.2921 mL	0.5841 mL	2.9206 mL
100 mM	0.0292 mL	0.1460 mL	0.2921 mL	1.4603 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc