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ML417
Catalog No. T8423Cas No. 1386162-69-1
ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $34 | In Stock | |
| 5 mg | $55 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $193 | In Stock | |
| 50 mg | $355 | In Stock | |
| 100 mg | $527 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $82 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM). |
| Targets&IC50 | D3:38 nM(EC50) |
| In vitro | Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity.?ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs.?Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders. |
| Molecular Weight | 379.45 |
| Formula | C22H25N3O3 |
| Cas No. | 1386162-69-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.18 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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