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ML417
🥰Excellent
Catalog No. T8423Cas No. 1386162-69-1
ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM).
ML417
🥰Excellent
Purity: 99.42%
Catalog No. T8423Cas No. 1386162-69-1
ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $59 | In Stock | |
| 25 mg | $116 | In Stock | |
| 50 mg | $213 | In Stock | |
| 100 mg | $316 | In Stock | |
| 200 mg | $457 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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CitedSelect Batch
Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML417 is a selective and brain-penetrant agonist of D3 dopamine (EC50: 38 nM). |
| Targets&IC50 | D3:38 nM(EC50) |
| In vitro | Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity.?ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs.?Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders. |
| Molecular Weight | 379.45 |
| Formula | C22H25N3O3 |
| Cas No. | 1386162-69-1 |
| Smiles | COc1ccc(OCCN2CCN(CC2)C(=O)c2cc3ccccc3[nH]2)cc1 |
| Relative Density. | 1.231 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (13.18 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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