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Apelin-12 acetate

Catalog No. T39823L CAS T39823L

Synonyms: Apelin-12 acetate (229961-08-4 Free base)

Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.

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Apelin-12 acetate, CAS T39823L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 228.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
1 mL * 10 mM (in DMSO)	In stock	$ 797.00

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Purity: 98.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Apelin-12 acetate significantly improves the neurobehavioral score of the mice with ischemia-reperfusion injury and alleviates brain edema and damage to neurons. Apelin-12 acetate inhibits the morphological changes and apoptosis of neuronal cells in the ischemic penumbra of mice. Apelin-12 acetate downregulates the expression of Bax and caspase-3, inhibits the activity of caspase-3, and upregulates the expression of Bcl-2, an anti-apoptotic protein[2].

Synonyms	Apelin-12 acetate (229961-08-4 Free base)
Molecular Weight	1482.75
Formula	C66H107N21O16S
CAS No.	T39823L

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (15.17 mM)

References and Literature

1. Yin C, et al. Adropin and apelin-12 efficiently predict metabolic syndrome in obese children. Pediatr Diabetes. 2020 Nov;21(7):1132-1139. 2. Liu DR, Hu W, Chen GZ. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3888-3895.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Obesity Compound Library Anti-Colorectal Cancer Compound Library Anti-Prostate Cancer Compound Library

Related Products

Related compounds with same targets

ML221 Azelaprag ELA-14(human) acetate BMS-986224 [Pyr1]-Apelin-13 (2R,3S)-Azelaprag ELA-11 (human) acetate(1784687-32-6 free base) (Ala13)-Apelin-13 acetate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Apelin-12 acetate T39823L GPCR/G Protein MAPK p38 MAPK Apelin receptor JNK Apelin-12 Acetate 229961-08-4 229961-08-4 Free base Apelin-12 acetate (229961-08-4 Free base) inhibitor inhibit

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