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(+)-JJ-74-138

Catalog No. T200319Cas No. 2135545-34-3

(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).

(+)-JJ-74-138

(+)-JJ-74-138

Catalog No. T200319Cas No. 2135545-34-3
(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).
In vitro
(+)-JJ-74-138, a potent analog of JJ-450, effectively inhibits androgen-independent activation of the androgen receptor (AR) in cell lines expressing splice variants of AR lacking the LBD. It suppresses mRNA expression of AR and ARv7 target genes and reduces nuclear AR levels in the absence of androgens.
Chemical Properties
Molecular Weight514.48
FormulaC22H22F8N2OS
Cas No.2135545-34-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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