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(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | (+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC). |
In vitro | (+)-JJ-74-138, a potent analog of JJ-450, effectively inhibits androgen-independent activation of the androgen receptor (AR) in cell lines expressing splice variants of AR lacking the LBD. It suppresses mRNA expression of AR and ARv7 target genes and reduces nuclear AR levels in the absence of androgens. |
Molecular Weight | 514.48 |
Formula | C22H22F8N2OS |
Cas No. | 2135545-34-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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