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(S)-AMPA HCl
🥰Excellent
Catalog No. T21271L
Alias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.
(S)-AMPA HCl
🥰Excellent
Catalog No. T21271LAlias L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base)
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 243 € | In Stock | |
| 5 mg | 535 € | In Stock | |
| 10 mg | 804 € | In Stock | |
| 25 mg | 1.354 € | In Stock | |
| 50 mg | 2.032 € | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease. |
| Targets&IC50 | AMPA:3.1 μM (EC50) |
| In vitro | (S)-AMPA HCl is a potent and selective AMPA receptor agonist. (S)-AMPA HCl (1 μM) infusion significantly reduced CGRP release in a CB-dependent manner. [1] In cultured mouse cortical neurons, (S)-AMPA HCl induces apoptotic states such as cell contraction, neurite vesicles and nuclear enrichment, with an EC50 of 3.1 μM.[2] |
| In vivo | Single focal injection of the (S)-AMPA HCl（6 nmol/microliters) into rat dorsal hippocampus resulted in widespread neurodegeneration with 90-100% loss of hippocampal pyramidal cells in CA1, CA2, CA3 and CA4 subfields, and 50-70% loss of dentate granule (DG) cells.[3] |
| Alias | L-AMPA HCl, (S)-AMPA HCl(83643-88-3 Free base) |
| Molecular Weight | 222.63 |
| Formula | C7H11ClN2O4 |
| Smiles | Cl.Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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