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(S)-FTY720-phosphonate
Catalog No. T78091Cas No. 1142015-10-8
FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury.
(S)-FTY720-phosphonate
Catalog No. T78091Cas No. 1142015-10-8
FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury. |
| In vitro | FTY720 (S)-Phosphate acts as an S1PR1 agonist, sustaining its protein expression and reinforcing the endothelial cell barrier in human pulmonary arteries through S1PR1 without promoting its ubiquitination. Moreover, at concentrations ranging from 0.01 to 50 μM, FTY720 (S)-Phosphate diminishes β-arrestin association with S1PR1 [1]. |
| In vivo | FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) maintains S1PR1 expression, protects against bleomycin-induced acute lung injury (ALI), and reduces leukocyte infiltration in the lung tissues of bleomycin-injured mice [1]. |
| Molecular Weight | 385.48 |
| Formula | C20H36NO4P |
| Cas No. | 1142015-10-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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