Shopping Cart
- Remove All
Your shopping cart is currently empty
CYM50260
CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.
Catalog No. T15031Cas No. 1355026-60-6
Select Batch
Purity:99.88%
Contact us for more batch information
CYM50260
Catalog No. T15031Cas No. 1355026-60-6
CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $29 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $113 | In Stock | |
| 25 mg | $238 | In Stock | |
| 50 mg | $356 | In Stock | |
| 100 mg | $535 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "CYM50260"
Siponimod
Cited
BAF-312
T64031230487-00-9
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibits >1000-fold over S1P2, S1P3 and S1P4 receptors.
- $33
Size
QTY
CitedFingolimod Cited
FTY-720A, FTY-720
T7939162359-55-9
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
- $50
Size
QTY
CitedKi16198
T6347355025-13-7
Ki16198 is an orally available LPA receptor antagonist and is a methyl ester derivative of Ki16425. It inhibits LPA1- and LPA3-induced inositol phosphates with Ki values of 0.34 and 0.93 μM, respectively, and can be used in studies of pancreatic carcinogenesis and metastasis.
- $48
Size
QTY
Ozanimod
RPC-1063
T69231306760-87-1
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis.
- $41
Size
QTY
Tyloxapol Cited
Triton WR1339
T030725301-02-4
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer utilized as a surfactant.
- $30
Size
QTY
CitedS1PR1 modulator 1
T128212328109-05-1In house
S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.
- $59
Size
QTY
ASP-4058
T10385952565-91-2In house
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.
Inquiry
SLP9101555
T63047In house
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.
- $350
Size
QTY
Fingolimod hydrochloride
FTY720, Fingolimod (FTY720) HCl
T2539162359-56-0
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
- $35
Size
QTY
CYM50308
T150321345858-76-5
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
- $34
Size
QTY
Ki16425
Debio 0719
T6108355025-24-0
Ki16425 (Debio 0719) is a competitive, potent, and reversible antagonist to LPA1, LPA2, and LPA3, with Ki values of 0.34 μM, 6.5 μM, and 0.93 μM, respectively.
- $31
Size
QTY
CYM-5541
ML249, CYM 5541, CID-17253208
T3961945128-26-7
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
- $32
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | CYM50260 is a potent and highly selective agonist of the sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM), exhibiting no activity against S1P1-R, S1P2-R, S1P3-R, and S1P5-R. |
| Targets&IC50 | S1P4 R:（EC50）45 nM |
| In vitro | CYM50260 is a synthetic agonist of S1P4-R. CYM50260 suppresses the collagen-stimulated platelet aggregation, sCD40L release and PDGF-AB secretion. CYM50260 is found 3.5-fold more potent than the hit compound (HTS-hit)[1]. CYM50260 decreases the release of phosphorylated-HSP27 by collagen as well as the phosphorylation of HSP27[2]. |
| Molecular Weight | 350.6 |
| Formula | C14H11Cl3FNO2 |
| Cas No. | 1355026-60-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (142.61 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy CYM50260 | purchase CYM50260 | CYM50260 cost | order CYM50260 | CYM50260 chemical structure | CYM50260 in vitro | CYM50260 formula | CYM50260 molecular weight
- TOP
Feedback
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.