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CYM50308

🥰Excellent
Catalog No. T15032Cas No. 1345858-76-5

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.

CYM50308

CYM50308

🥰Excellent
Purity: 99.63%
Catalog No. T15032Cas No. 1345858-76-5
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
Pack SizePriceAvailabilityQuantity
1 mg$56In Stock
5 mg$143In Stock
10 mg$213In Stock
25 mg$342In Stock
50 mg$479In Stock
100 mg$629In Stock
200 mg$886In Stock
500 mg$1,290In Stock
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Purity:99.63%
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Product Introduction

Bioactivity
Description
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.
Targets&IC50
S1P4:(EC50)56 nM, S1P5:2100 nM(EC50)
In vitro
CYM50308 shows low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1].
Chemical Properties
Molecular Weight405.46
FormulaC20H21F2N3O2S
Cas No.1345858-76-5
SmilesCOCC\N=C1/S\C(=C/c2cc(C)n(c2C)-c2ccc(F)cc2F)C(=O)N1C
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1 mg/ml, Sonication is recommended.

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