Shopping Cart
- Remove All
Your shopping cart is currently empty
A-794282
🥰Excellent
Catalog No. T26486Cas No. 869802-44-8
Alias A794282, A 794282
A-794282 is a selective and potent mGlu1 receptor antagonist with analgesic activity and may be useful in the study of neurologic disorders.
A-794282
🥰Excellent
Catalog No. T26486Alias A794282, A 794282Cas No. 869802-44-8
A-794282 is a selective and potent mGlu1 receptor antagonist with analgesic activity and may be useful in the study of neurologic disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 2 mg | $436 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "A-794282"
L-Glutamine
Cited
L-Glutamic acid 5-amide
T0326L56-85-9
L-Glutamine (L-Glutamic acid 5-amide), a non-essential amino acid, is synthesized from glutamic acid and ammonia.
- $29
Size
QTY
CitedL-Glutamic acid monosodium salt
MSG, Monosodium glutamate, Glutavene, Glutacyl, Ajinomoto
T6871142-47-2
L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor.
- $33
Size
QTY
O-Phospho-L-serine
Phosphoserine, L-SOP, L-Serine O-phosphate, Dexfosfoserine
T1324407-41-0
O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.
- $33
Size
QTY
Evans blue
Direct Blue 53, C.I. 23860
T0313314-13-6
Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
- $41
Size
QTY
Direct Blue 1
Pontamine sky blue, Chicago Sky Blue 6B
T21942610-05-1
Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and operates as a potent, competitive VGLUT inhibitor, not impacting plasma membrane transporters. This compound stands out as the inaugural small molecule PrP ligand to inhibit Aβ binding.
- $42
Size
QTY
Piracetam
UCB-6215
T04267491-74-9
Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
- $45
Size
QTY
Decanoic Acid
Decoic acid, Caprynic acid, CAPRIC ACID
T3379334-48-5
Decanoic Acid (Caprynic acid) acts as a non-competitive AMPA receptor antagonist.
- $42
Size
QTY
Memantine hydrochloride Cited
Namenda, Memantine HCl, D-145 (hydrochloride)
T144341100-52-1
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
- $42
Size
QTY
CitedL-Cysteic acid monohydrate
3-Sulfo-L-alanine Monohydrate
T508323537-25-9
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) is an oxidation product of L-cysteine that may be used as a competitive inhibitor of the bacterial aspartate: alanine antiporter (AspT) exchange of aspartate and in other aspartate biological systems. L-Cysteic acid monohydrate is used in monomeric surfactant development. L-Cysteic acid monohydrate may be used in studies of excitatory amino acids in the brain, such as those that bind to cysteine sulfinic acid receptors. It is a useful agonist at several rat metabotropic glutamate receptors (mGluRs).
- $29
Size
QTY
DCB
3,3'-dichlorobenzaldazine
T227116971-97-7
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of 3,3′-difluorobenzaldazine (DFB).
- $33
Size
QTY
Topiramate
RWJ 17021, McN 4853
T067597240-79-4
Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and largely when used in combination with other anticonvulsant medications.
- $38
Size
QTY
Select Batch
Purity:≥98%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | A-794282 is a selective and potent mGlu1 receptor antagonist with analgesic activity and may be useful in the study of neurologic disorders. |
| In vivo | METHODS: In this study, the effects of A-794282, a potent and selective mGlu1 receptor antagonist (ip) were evaluated in a rat skin incision-induced postoperative pain model. Postoperative pain was examined 2 h after surgery, using the difference in weight bearing between the injured and uninjured paws as a measure of spontaneous pain. RESULTS: In this model, A-794282 significantly attenuated spontaneous postoperative pain behaviors induced by A-794282, with an ED50 of 50 μmol/kg, respectively. [2] |
| Alias | A794282, A 794282 |
| Molecular Weight | 350.44 |
| Formula | C19H18N4OS |
| Cas No. | 869802-44-8 |
| Smiles | O=C1C=2SC3=NC=CC(=C3C2N=CN1C4=CC=C(C=C4)CC)N(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy A-794282 | purchase A-794282 | A-794282 cost | order A-794282 | A-794282 chemical structure | A-794282 in vivo | A-794282 formula | A-794282 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.