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AA92593

AA92593
AA92593 has been used as a selective inhibitor of melanopsin.
Catalog No. T8566Cas No. 457961-34-1
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Purity:99.71%
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AA92593

Catalog No. T8566Cas No. 457961-34-1

AA92593 has been used as a selective inhibitor of melanopsin.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$80In Stock
25 mg$163In Stock
50 mg$288In Stock
100 mg$490In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Product Introduction

Bioactivity
Description
AA92593 has been used as a selective inhibitor of melanopsin.
In vitro
The involvement of melanopsin in the regulation of melatonin was also determined by using a specific inhibitor AA92593 and by inhibiting melanopsin-induced phospholipase C activation. Under this situation neither AANAT nor melatonin levels changed under light conditions (n = 4, ***p < 0.001). The discovery of melanopsin in the lens opens the possibility of regulating melatonin synthesis with the corresponding implication as an antioxidant substance[1].
Chemical Properties
Molecular Weight269.36
FormulaC13H19NO3S
Cas No.457961-34-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (83.53 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7125 mL18.5625 mL37.1250 mL185.6252 mL
5 mM0.7425 mL3.7125 mL7.4250 mL37.1250 mL
10 mM0.3713 mL1.8563 mL3.7125 mL18.5625 mL
20 mM0.1856 mL0.9281 mL1.8563 mL9.2813 mL
50 mM0.0743 mL0.3713 mL0.7425 mL3.7125 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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