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Alclometasone dipropionate

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Catalog No. T21361Cas No. 66734-13-2
Alias Vaderm, Sch 22219, Delonal, Aclovate

Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.

Alclometasone dipropionate
Other Forms of Alclometasone dipropionate:
AlclometasoneT1415467452-97-5
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Alclometasone dipropionate

🥰Excellent
Purity: 99.62%
Catalog No. T21361Alias Vaderm, Sch 22219, Delonal, AclovateCas No. 66734-13-2
Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.
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10 mg$69In Stock
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Purity:99.62%
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COA HNMR HPLC
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Product Introduction

Bioactivity
Description
Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.
In vitro
The suppressive effect of tacrolimus on cytokine production was stronger than that of alclometasone dipropionate and equal to or stronger than that of betamethason valerate. The effective dose of tacrolimus (IC50, 0.02-0.11 ng/ml) is almost the same as for Th1 and Th2 cytokines, and 1 ng/ml of tacrolimus suppressed all cytokines completely[1].
In vivo
In Lewis rats with tuberculin-induced delayed-type hypersensitivity reaction, alclometasone dipropionate (0.1% (20μL, administered once to the ear) partially inhibited the increase in dye leakage, indicating its impact on hypersensitivity reactions induced by tuberculin and ovalbumin [2].
AliasVaderm, Sch 22219, Delonal, Aclovate
Chemical Properties
Molecular Weight521.04
FormulaC28H37ClO7
Cas No.66734-13-2
SmilesC(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(C[C@H]3Cl)=CC(=O)C=C4)[H])[H])[H]
Relative Density.1.26g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 5 mg/mL (9.60 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9192 mL9.5962 mL19.1924 mL95.9619 mL
5 mM0.3838 mL1.9192 mL3.8385 mL19.1924 mL

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Keywords

AlmetaAlclometasone
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