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Alclometasone dipropionate

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Purity:99.62%

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COA HNMR HPLC

Alclometasone dipropionate

Catalog No. T21361Cas No. 66734-13-2

Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.

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Pack Size	Price	Availability	Quantity
10 mg	$69	In Stock

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Product Introduction

Bioactivity

Description	Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.
In vitro	The suppressive effect of tacrolimus on cytokine production was stronger than that of alclometasone dipropionate and equal to or stronger than that of betamethason valerate. The effective dose of tacrolimus (IC50, 0.02-0.11 ng/ml) is almost the same as for Th1 and Th2 cytokines, and 1 ng/ml of tacrolimus suppressed all cytokines completely[1].
In vivo	In Lewis rats with tuberculin-induced delayed-type hypersensitivity reaction, alclometasone dipropionate (0.1% (20μL, administered once to the ear) partially inhibited the increase in dye leakage, indicating its impact on hypersensitivity reactions induced by tuberculin and ovalbumin [2].
Alias	Vaderm, Sch 22219, Aclovate, Delonal

Chemical Properties

Molecular Weight	521.04
Formula	C28H37ClO7
Cas No.	66734-13-2

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 5 mg/mL (9.60 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1919 mL	0.9596 mL	1.9192 mL	9.5962 mL
20 mM	0.0960 mL	0.4798 mL	0.9596 mL	4.7981 mL
50 mM	0.0384 mL	0.1919 mL	0.3838 mL	1.9192 mL
100 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.9596 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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