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Aleglitazar
Catalog No. T14176Cas No. 475479-34-6
Alias RO0728804, R1439
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.
Aleglitazar
Catalog No. T14176Alias RO0728804, R1439Cas No. 475479-34-6
Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $258 | In Stock | |
| 5 mg | $592 | In Stock | |
| 10 mg | $798 | In Stock | |
| 25 mg | $1,220 | In Stock | |
| 50 mg | $1,650 | In Stock | |
| 100 mg | $2,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $598 | In Stock |
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Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes. |
| Targets&IC50 | PPARγ:19 nM, PPARα:38 nM |
| In vitro | Aleglitazar exhibits species selectivity for PPARα, with EC50 values of 50 nM, 2.26 μM, and 2.34 μM for human, rat, and mouse PPARα, respectively[1]. At concentrations of 0.01-40 μM (12-48 hours), aleglitazar does not significantly increase lactate dehydrogenase (LDH) release at 0.1-20 μM but shows significant increases at 30 μM and 40 μM[2]. Additionally, aleglitazar (0.01-20 μM; 48 hours) decreases hyperglycemia (HG, glucose 25 mM)-induced apoptosis, caspase-3 activity, and cytochrome-C release, while improving cell viability in hyperglycemic conditions[2]. |
| In vivo | Aleglitazar (0.3-3.0 mg/kg; i.p.; daily; for 7 days) exerts beneficial effects on structural and functional outcomes of mild brain ischemia, reduces key aspects of microglia activation including NO production, release of proinflammatory cytokines, migration, and phagocytosis, and attenuates inflammatory responses in the post-ischemic brain[3]. |
| Alias | RO0728804, R1439 |
| Molecular Weight | 437.51 |
| Formula | C24H23NO5S |
| Cas No. | 475479-34-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (102.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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