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ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK/EGFR mutants with IC50 values of 4.3 nM for EGFR L858R T790M in H1975 cells and 3.6 nM for EML4-ALK in BaF3 cells. This compound may be applicable in the research of non-small cell lung cancer (NSCLC) [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,670 | 8-10 weeks | |
50 mg | $2,180 | 8-10 weeks | |
100 mg | $2,800 | 8-10 weeks |
Description | ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK/EGFR mutants with IC50 values of 4.3 nM for EGFR L858R T790M in H1975 cells and 3.6 nM for EML4-ALK in BaF3 cells. This compound may be applicable in the research of non-small cell lung cancer (NSCLC) [1]. |
Molecular Weight | 572.12 |
Formula | C27H34ClN7O3S |
Cas No. | 2730430-08-5 |
Storage | Shipping with blue ice. |
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