alpha-Amanitin

Name: alpha-Amanitin
Brand: TargetMol
SKU: T13540
Price: 45 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T13540Cas No. 23109-05-9

Alias α-Amatoxin, α-Amanitin

alpha-Amanitin (alpha-Amanitin) is the lethal toxin in Trichoderma viride and acts in vivo via the enterohepatic circulation and transport system. alpha-Amanitin induces cell death and can be used in the synthesis of ADCs. alpha-Amanitin has been shown to induce cell death and can be used in the synthesis of ADCs.

alpha-Amanitin

Catalog No. T13540Alias α-Amatoxin, α-AmanitinCas No. 23109-05-9

Pack Size	Price	Availability	Quantity
100 μg	$298	Backorder
500 μg	$648	Backorder

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Purity:≥90%

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Product Introduction

Bioactivity

Description	alpha-Amanitin (alpha-Amanitin) is the lethal toxin in Trichoderma viride and acts in vivo via the enterohepatic circulation and transport system. alpha-Amanitin induces cell death and can be used in the synthesis of ADCs. alpha-Amanitin has been shown to induce cell death and can be used in the synthesis of ADCs.
In vitro	alpha-Amanitin, an RNA polymerase II (RNAPII) inhibitor, effectively inhibited DTCs by suppressing TAF15 expression, which binds to RNA to modulate transcription and RNA processing[2].
In vivo	Sequential administration of alpha-Amanitin (0.4 mg/kg, ip) and cisplatin prolonged the overall survival of cancer recurrence in murine models (i.e., peritoneal carcinomatosis)[2].
Alias	α-Amatoxin, α-Amanitin

Chemical Properties

Molecular Weight	918.97
Formula	C₃₉H₅₄N₁₀O₁₄S
Cas No.	23109-05-9

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 80 mg/mL (87.05 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.0882 mL	5.4409 mL	10.8817 mL	54.4087 mL
5 mM	0.2176 mL	1.0882 mL	2.1763 mL	10.8817 mL
10 mM	0.1088 mL	0.5441 mL	1.0882 mL	5.4409 mL
20 mM	0.0544 mL	0.2720 mL	0.5441 mL	2.7204 mL
50 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0882 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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