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AN0128 (CRM-0005) is an anti-inflammatory boron-containing antibacterial agent that inhibits S. aureus, S. epidermidis, P. acnes, B. subtilis, and suppresses pro-inflammatory cytokine production in macrophage cell lines by inhibiting the p38 MAP kinase signaling pathway. It can be used in dermatological research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $58 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $140 | In Stock | |
25 mg | $290 | In Stock | |
50 mg | $456 | In Stock |
Description | AN0128 (CRM-0005) is an anti-inflammatory boron-containing antibacterial agent that inhibits S. aureus, S. epidermidis, P. acnes, B. subtilis, and suppresses pro-inflammatory cytokine production in macrophage cell lines by inhibiting the p38 MAP kinase signaling pathway. It can be used in dermatological research. |
In vitro | The minimum inhibitory concentration (MIC) of AN0128 (compound 2g) against S. aureus, S. epidermidis, P. acnes and B. subtilis were 1, 0.5, 0.3 and 1 μg/mL, respectively.[1] AN0128 (10 μM; 24-48 h) showed potent inhibition of the release of pro-inflammatory cytokines (TNF-α and IL-1β) in human peripheral blood mononuclear cells (PBMCs), but did not inhibit IFN-γ or IL-4 release. [1] |
In vivo | AN0128 (1%, 5%; topical application daily for 7 days) significantly inhibited the formation of inflammatory infiltrates and reduced bone loss. [2] |
Alias | ONT-0001, ONT0001, CRM-0005, CRM0005, AN 0128 |
Molecular Weight | 400.06 |
Formula | C20H16BCl2NO3 |
Cas No. | 872044-70-7 |
Smiles | O=C(OB(C1=CC=C(C(Cl)=C1)C)C2=CC=C(C(Cl)=C2)C)C3=NC=CC=C3O |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (249.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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