Shopping Cart
- Remove All
Your shopping cart is currently empty
Angiotensin II 5-valine TFA
🥰Excellent
Catalog No. TP1017L
Alias Angiotensin II 5-valine TFA(58-49-1 free base)
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
Angiotensin II 5-valine TFA
🥰Excellent
Purity: 99.69%
Catalog No. TP1017LAlias Angiotensin II 5-valine TFA(58-49-1 free base)
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $53 | In Stock | |
| 10 mg | $68 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $116 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Angiotensin II 5-valine TFA"
Captopril
Cited
SQ-14534, SQ 14225, SA333
T146262571-86-2
Captopril (SA333) is a potent and specific inhibitor of peptidyl-dipeptidase A. It blocks the conversion of angiotensin I to angiotensin II, a vasoconstrictor and important regulator of arterial blood pressure.
- $40
Size
QTY
CitedSacubitril/Valsartan
Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696
T2318936623-90-4
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
- $38
Size
QTY
Losartan Cited
DuP-753
T0215L114798-26-4
Losartan (DuP-753) is an angiotensin II receptor antagonist.
- $50
Size
QTY
CitedTranilast Cited
SB 252218, MK 341
T269053902-12-8
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.
- $36
Size
QTY
CitedIrbesartan
SR-47436, BMS-186295
T1615138402-11-6
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker whose mechanism of action involves antagonizing the Angiotensin 2 Receptor.
- $48
Size
QTY
Losartan potassium
MK 954, DuP-753 potassium, DuP 753
T0215124750-99-8
Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.
- $33
Size
QTY
Ramipril
Tritace, HOE-498, Carasel, Altace
T164587333-19-5
Ramipril (Altace) is a long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
- $40
Size
QTY
Enalapril Maleate
Vasotec Maleate, Renitec Maleate, MK-421 Maleate, MK-421 (maleate), Glioten Maleate
T648676095-16-4
Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy.
- $42
Size
QTY
Azilsartan Methyl Ester
T66580147403-52-9
Azilsartan Methyl Ester is an angiotensin II receptor antagonist. Azilsartan Methyl Ester inhibits specific binding of [125I]AII (0.2 nM) to bovine adrenal cortex with IC50 value is 0.44uM.
- $37
Size
QTY
Valsartan Methyl Ester
T67848137863-17-3
Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM.
- $38
Size
QTY
Azilsartan Cited
TAK-536
T1057147403-03-0
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker that acts as an Angiotensin 2 Type 1 Receptor Antagonist, leading to a physiologic effect of decreased blood pressure.
- $30
Size
QTY
CitedOlmesartan Medoxomil
CS 866, Benicar
T1518144689-63-4
Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension.
- $30
Size
QTY
Select Batch
Purity:99.69%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Angiotensin II 5-valine TFA is an agonist of angiotensin receptor. |
| In vivo | By day 12, systolic blood pressure (SBP) increased significantly in Val5-ANG II infused rats (197 +/- 7 mm Hg). As previously shown, the development of hypertension in ANG II infused rats was prevented by losartan treatment. Blood and kidney samples were harvested, subjected to HPLC to separate Val5-ANG II (exogenous) from Ile5-ANG II (endogenous) and the fractions were measured by radioimmunoassay. In the Val5-ANG II infused rats treated with losartan, total plasma ANG II levels were elevated to a greater extent than in rats not treated with losartan (289 +/- 20 v 119 +/- 14 fmol/mL). However, losartan markedly decreased by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone. These results demonstrate that AT1 receptor blockade markedly reduces the intrarenal uptake of circulating ANG II that occurs in ANG II induced hypertension. |
| Alias | Angiotensin II 5-valine TFA(58-49-1 free base) |
| Molecular Weight | 1146.18 |
| Formula | C51H70F3N13O14 |
| Smiles | O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)CC3=CNC=N3)=O)C(C)C)=O)CC4=CC=C(O)C=C4)=O)C(C)C)=O)CCCNC(N)=N.O=C(O)C(F)(F)F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Angiotensin II 5-valine TFA | purchase Angiotensin II 5-valine TFA | Angiotensin II 5-valine TFA cost | order Angiotensin II 5-valine TFA | Angiotensin II 5-valine TFA chemical structure | Angiotensin II 5-valine TFA in vivo | Angiotensin II 5-valine TFA formula | Angiotensin II 5-valine TFA molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.