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Angiotensin II 5-valine TFA
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Angiotensin II 5-valine TFA
Catalog No. TP1017L
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $53 | In Stock | |
| 10 mg | $68 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $116 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Angiotensin II 5-valine TFA is an agonist of angiotensin receptor. |
| In vivo | By day 12, systolic blood pressure (SBP) increased significantly in Val5-ANG II infused rats (197 +/- 7 mm Hg). As previously shown, the development of hypertension in ANG II infused rats was prevented by losartan treatment. Blood and kidney samples were harvested, subjected to HPLC to separate Val5-ANG II (exogenous) from Ile5-ANG II (endogenous) and the fractions were measured by radioimmunoassay. In the Val5-ANG II infused rats treated with losartan, total plasma ANG II levels were elevated to a greater extent than in rats not treated with losartan (289 +/- 20 v 119 +/- 14 fmol/mL). However, losartan markedly decreased by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone. These results demonstrate that AT1 receptor blockade markedly reduces the intrarenal uptake of circulating ANG II that occurs in ANG II induced hypertension. |
| Alias | Angiotensin II 5-valine TFA(58-49-1 free base) |
| Molecular Weight | 1146.18 |
| Formula | C51H70F3N13O14 |
| Cas No. |
| Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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