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Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
2 mg | $175 | In Stock | |
5 mg | $268 | In Stock | |
10 mg | $394 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $828 | In Stock | |
100 mg | $1,130 | In Stock | |
500 mg | $2,260 | In Stock | |
1 mL x 10 mM (in DMSO) | $322 | In Stock |
Description | Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells. |
In vitro | In RAW 264.7 cells, Antitumor agent-19 (10 µM, 20 µM, or 50 µM) effectively and dose-dependently induces the expression of M1-phenotype macrophage markers including IL-1β, TNF-α, iNOS and IL-12α. Antitumor agent-19 dose-dependently repolarizes tumor-associated macrophages from M1 (anti-tumor) and M2 (pro-tumor)[1]. |
In vivo | In C57BL/6 female mice with lewis lung cancer cells, Antitumor agent-19 (5 mg/kg; i.p.) remarkably inhibits tumor growth. The synergy of Antitumor agent-19 with anti-PD-1 antibody shows more superior antineoplastic effects in vivo[1]. |
Molecular Weight | 487.9 |
Formula | C24H21ClF3N5O |
Cas No. | 2379727-90-7 |
Smiles | N(C(NC1=CC(C(F)(F)F)=C(Cl)C=C1)=O)C2CC=3C4=C(C=CC=C4NC3CC2)C5=CN(C)N=C5 |
Relative Density. | 1.49 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (102.48 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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