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Apamin acetate
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Apamin acetate
Catalog No. TP1223L
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $183 | In Stock | |
| 5 mg | $415 | In Stock | |
| 10 mg | $597 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,290 | In Stock | |
| 100 mg | $1,730 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects. |
| In vitro | Apamin acetate (0.5-2 µg/mL; 24 h; HSC-T6 cells) treatment effectively diminishes α-SMA expression in TGF-β1-induced HSC-T6 cells. Furthermore, Apamin acetate treatment prevents the activation of p-Smad2/3 and Smad4 induced by TGF-β1.[1] |
| In vivo | Apamin acetate (0.1 mg/kg; i.p.; twice a week; for 4 weeks; C57BL/6 male mice) leads to reduced liver injury and lowered proinflammatory cytokine levels. Additionally, it inhibits collagen deposition, bile duct epithelial cell (BEC) proliferation, and the expression of fibrogenic genes in DDC-fed mice.[1] |
| Alias | Apamine acetate, Apamin acetate(24345-16-2 Free base) |
| Cas No. |
| Storage | store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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