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Apamin acetate
Catalog No. TP1223L
Alias Apamine acetate, Apamin acetate(24345-16-2 Free base)
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects.
Apamin acetate
Catalog No. TP1223LAlias Apamine acetate, Apamin acetate(24345-16-2 Free base)
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $183 | In Stock | |
| 5 mg | $415 | In Stock | |
| 10 mg | $597 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,290 | In Stock | |
| 100 mg | $1,730 | In Stock |
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Purity:96.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects. |
| In vitro | Apamin acetate (0.5-2 µg/mL; 24 h; HSC-T6 cells) treatment effectively diminishes α-SMA expression in TGF-β1-induced HSC-T6 cells. Furthermore, Apamin acetate treatment prevents the activation of p-Smad2/3 and Smad4 induced by TGF-β1.[1] |
| In vivo | Apamin acetate (0.1 mg/kg; i.p.; twice a week; for 4 weeks; C57BL/6 male mice) leads to reduced liver injury and lowered proinflammatory cytokine levels. Additionally, it inhibits collagen deposition, bile duct epithelial cell (BEC) proliferation, and the expression of fibrogenic genes in DDC-fed mice.[1] |
| Alias | Apamine acetate, Apamin acetate(24345-16-2 Free base) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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