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ARB-272572
🥰Excellent
Catalog No. T39914Cas No. 2368182-63-0
Alias ARB272572, ARB 272572
ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
ARB-272572
🥰Excellent
Catalog No. T39914Alias ARB272572, ARB 272572Cas No. 2368182-63-0
ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $159 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $496 | In Stock | |
| 25 mg | $828 | In Stock | |
| 50 mg | $1,220 | In Stock | |
| 100 mg | $1,650 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells. |
| Targets&IC50 | PD-1/PD-L1:400 pM |
| In vitro | METHODS: Small molecules were screened in a cell-free in vitro homogeneous time-resolved fluorescence (HTRF) assay using αPD-L1 (MIH1) and αPD-1 (nivolumab) antibodies as positive controls.
RESULTS: ARB-272572 inhibited PD-1/PD-L1 with an IC50 value of 400 pM.[1] |
| In vivo | "METHODS: PD-1/PD-L1 humanized mice implanted with MC38 cells expressing humanized PD-L1 and treated with ARB-272572 (10 mg/kg orally, 7 times daily, days 0-6) or αPD-L1 (10 mg/kg intraperitoneally, 3 times per week, days 0-16). Statistically significant tumor growth inhibition was observed with αPD-L1 antibody or Compound A treatment.
RESULTS:ARB-272572 treatment resulted in a 60.4% reduction in mean tumor volume in 60.4% of mice after only 7 days. [1]" |
| Alias | ARB272572, ARB 272572 |
| Molecular Weight | 568.67 |
| Formula | C32H36N6O4 |
| Cas No. | 2368182-63-0 |
| Smiles | O=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL（175.85 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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