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AZ-23

Name: AZ-23
Brand: TargetMol
SKU: T14363
Price: 94 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14363Cas No. 915720-21-7

Alias AZ23, AZ 23

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

AZ-23

🥰Excellent

Purity: 99.4%

Catalog No. T14363Alias AZ23, AZ 23Cas No. 915720-21-7

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

Pack Size	Price	Availability	Quantity
1 mg	94 €	In Stock

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Purity:99.4%

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COA LCMS

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Product Introduction

Bioactivity

Description	AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
Targets&IC50	TrkB:8 nM, TrkA:2 nM
In vitro	AZ-23 selectively and potently inhibits Trk phosphorylation in cells, with an EC50 of 2 nM for Trk-mediated survival. It also inhibits Trk-dependent survival in MCF10ATrkA-Δ and TF-1 cell lines[1].
In vivo	Following oral administration in a TrkA-driven allograft model, AZ-23 demonstrates effective in vivo inhibition of TrkA kinase and efficacy in mice. It also significantly inhibits tumor growth in a Trk-expressing xenograft model of neuroblastoma[1].
Alias	AZ23, AZ 23

Chemical Properties

Molecular Weight	391.83
Formula	C₁₇H₁₉ClFN₇O
Cas No.	915720-21-7
Smiles	CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)n[nH]1
Relative Density.	1.411 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (319.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5521 mL	12.7606 mL	25.5213 mL	127.6064 mL
5 mM	0.5104 mL	2.5521 mL	5.1043 mL	25.5213 mL
10 mM	0.2552 mL	1.2761 mL	2.5521 mL	12.7606 mL
20 mM	0.1276 mL	0.6380 mL	1.2761 mL	6.3803 mL
50 mM	0.0510 mL	0.2552 mL	0.5104 mL	2.5521 mL
100 mM	0.0255 mL	0.1276 mL	0.2552 mL	1.2761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AZ-23

AZ-23

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Keywords