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AZ12216052

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Purity:99.29%

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COA HNMR HPLC

AZ12216052

Catalog No. T26701Cas No. 1290628-31-7

AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.

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Pack Size	Price	Availability
1 mg	$100	In Stock
2 mg	$147	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$648	In Stock
50 mg	$912	In Stock
100 mg	$1,220	In Stock
500 mg	$2,460	In Stock

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Product Introduction

Bioactivity

Description	AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.
In vitro	In UN- and RA-SH-SY5Y cells, AZ 12216052 (0.01-1 μM; 48 hours) increased cell viability at 0.1 μM and protected undifferentiated neuroblastoma cells against the damaging effects of Iri or Cis[2].
In vivo	AZ 12216052 (10 mg/kg; intraperitoneal injection; single dose, 2 hours prior to testing) reduced the increased anxiety levels in ApoE−/− and C57BL/6J mice in the zero maze without affecting the speed of the mice. Additionally, it decreased the acoustic startle response[3].
Alias	AZ 12216052, AZ-12216052

Chemical Properties

Molecular Weight	392.35
Formula	C19H22BrNOS
Cas No.	1290628-31-7

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (203.90 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5487 mL	12.7437 mL	25.4874 mL	127.4372 mL
5 mM	0.5097 mL	2.5487 mL	5.0975 mL	25.4874 mL
10 mM	0.2549 mL	1.2744 mL	2.5487 mL	12.7437 mL
20 mM	0.1274 mL	0.6372 mL	1.2744 mL	6.3719 mL
50 mM	0.0510 mL	0.2549 mL	0.5097 mL	2.5487 mL
100 mM	0.0255 mL	0.1274 mL	0.2549 mL	1.2744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc