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BAY 73-1449

🥰Excellent
Catalog No. T26745Cas No. 693790-96-4
Alias BAY73-1449, BAY-73-1449

BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).

BAY 73-1449

BAY 73-1449

🥰Excellent
Purity: 99.58%
Catalog No. T26745Alias BAY73-1449, BAY-73-1449Cas No. 693790-96-4
BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).
Pack SizePriceAvailabilityQuantity
1 mg$53In Stock
2 mg$75In Stock
5 mg$119In Stock
10 mg$197In Stock
25 mg$341In Stock
50 mg$490In Stock
100 mg$653In Stock
200 mg$879In Stock
1 mL x 10 mM (in DMSO)$136In Stock
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Purity:99.58%
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Product Introduction

Bioactivity
Description
BAY 73-1449 is a potent and selective antagonist of the prostacyclin receptor (IC50 < 0.1 nM).
Targets&IC50
Prostacyclin receptor:<0.1 nM
In vivo
In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow[1]. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats[1].
AliasBAY73-1449, BAY-73-1449
Chemical Properties
Molecular Weight425.48
FormulaC26H23N3O3
Cas No.693790-96-4
SmilesOC(=O)[C@@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1
Relative Density.1.273 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (129.27 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3503 mL11.7514 mL23.5029 mL117.5143 mL
5 mM0.4701 mL2.3503 mL4.7006 mL23.5029 mL
10 mM0.2350 mL1.1751 mL2.3503 mL11.7514 mL
20 mM0.1175 mL0.5876 mL1.1751 mL5.8757 mL
50 mM0.0470 mL0.2350 mL0.4701 mL2.3503 mL
100 mM0.0235 mL0.1175 mL0.2350 mL1.1751 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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