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Beta-Sheet Breaker Peptide iAβ5 Acetate

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Purity:99.68%

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COA MS HPLC

Beta-Sheet Breaker Peptide iAβ5 Acetate

Catalog No. T21609L

Beta-Sheet Breaker Peptide iAβ5 Acetate (C33H43N5O8) inhibit amyloidogenesis in rat brain models.

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Pack Size	Price	Availability
5 mg	$53	In Stock
10 mg	$74	In Stock
25 mg	$97	In Stock
50 mg	$157	In Stock
100 mg	$236	In Stock
200 mg	$353	In Stock
500 mg	$531	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Product Introduction

Bioactivity

Description	Beta-Sheet Breaker Peptide iAβ5 Acetate (C33H43N5O8) inhibit amyloidogenesis in rat brain models.
In vivo	5-residue peptide that inhibits amyloid beta-protein fibrillogenesis, disassembles preformed fibrils in vitro and prevents neuronal death induced by fibrils in cell culture. In addition, the beta-sheet breaker peptide significantly reduces amyloid beta-protein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. These findings may provide the basis for a new therapeutic approach to prevent amyloidosis in Alzheimer's disease.
Alias	Beta-Sheet Breaker Peptide iAβ5 Acetate(182912-74-9 Free base)

Chemical Properties

Molecular Weight	697.78
Formula	C35H47N5O10
Cas No.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (94.08 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4331 mL	7.1656 mL	14.3312 mL	71.6558 mL
5 mM	0.2866 mL	1.4331 mL	2.8662 mL	14.3312 mL
10 mM	0.1433 mL	0.7166 mL	1.4331 mL	7.1656 mL
20 mM	0.0717 mL	0.3583 mL	0.7166 mL	3.5828 mL
50 mM	0.0287 mL	0.1433 mL	0.2866 mL	1.4331 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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