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Blosozumab
🥰Excellent
Catalog No. T78278Cas No. 1132758-87-2
Alias TST-002, TST002, LY-2541546, LY2541546
Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.
Blosozumab
Blosozumab
🥰Excellent
Catalog No. T78278Alias TST-002, TST002, LY-2541546, LY2541546Cas No. 1132758-87-2
Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $629 | In Stock | |
| 10 mg | $993 | In Stock | |
| 25 mg | $1,470 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Concentration:5.64 mg/mL
Purity:>95%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Blosozumab (LY2541546) is a humanized monoclonal antibody targeting sclerostin, promoting bone formation and inhibiting bone resorption, used in osteoporosis research. Blosozumab increases bone mass by neutralizing the negative effects of sclerostin on the Wnt signaling pathway. |
| In vivo | Blosozumab is a humanized monoclonal antibody (IgG4) that has been optimized for neutralizing the sclerosing protein. In 5 - and 6-month non-clinical safety studies in rats, Blosozumab resulted in a dose-dependent, reversible reduction in platelet counts, accompanied by accelerated platelet production, increased megakaryocyte growth, and altered megakaryocyte morphology. There was no change in platelet counts or megakaryocytes in cynomophagus monkeys treated with Blosozumab. [1] |
| Alias | TST-002, TST002, LY-2541546, LY2541546 |
| Cas No. | 1132758-87-2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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