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BMS-779788
Catalog No. T3970Cas No. 918348-67-1
Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
BMS-779788
Catalog No. T3970Alias XL-652, XL652, XL 652, EXEL04286652, BMS-788Cas No. 918348-67-1
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $32 | In Stock | |
| 5 mg | $51 | In Stock | |
| 10 mg | $76 | In Stock | |
| 25 mg | $159 | In Stock | |
| 50 mg | $263 | In Stock | |
| 100 mg | $413 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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Purity:99.24%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). |
| Targets&IC50 | LXRα:68nM, LXRβ:14 nM |
| In vitro | BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM). |
| In vivo | BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2]. |
| Alias | XL-652, XL652, XL 652, EXEL04286652, BMS-788 |
| Molecular Weight | 509.06 |
| Formula | C28H29ClN2O3S |
| Cas No. | 918348-67-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (117.86 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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