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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $916 | 6-8 weeks | |
50 mg | $1,190 | 6-8 weeks | |
100 mg | $1,860 | 6-8 weeks |
Description | BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM). |
In vitro | BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days and long-term treatment leads to ceasing cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces the senescence program in H1299 cells. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments [1]. |
In vivo | The treatment of BMVC (1 mg/kg; i.p.; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) delays tumorigenic potential of cancer cells in vivo [1]. |
Molecular Weight | 657.33 |
Formula | C28H25I2N3 |
Cas No. | 627810-06-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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