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Brolucizumab
😃Good
Catalog No. T80593Cas No. 1531589-13-5
Alias RTH258, ESBA 1008, DLX1008
Brolucizumab (DLX1008) is a single-chain anti-VEGF-A antibody fragment with low picomolar affinity (K D = 1.05 pM), used for cancer research [1][2].
Brolucizumab
Brolucizumab
😃Good
Catalog No. T80593Alias RTH258, ESBA 1008, DLX1008Cas No. 1531589-13-5
Brolucizumab (DLX1008) is a single-chain anti-VEGF-A antibody fragment with low picomolar affinity (K D = 1.05 pM), used for cancer research [1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $247 | 8-10 weeks | |
| 5 mg | $645 | 8-10 weeks | |
| 10 mg | $987 | 8-10 weeks | |
| 25 mg | $1,530 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,790 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Brolucizumab (DLX1008) is a single-chain anti-VEGF-A antibody fragment with low picomolar affinity (K D = 1.05 pM), used for cancer research [1][2]. |
| In vitro | Brolucizumab, at a concentration of 2683 nM, inhibits VEGF-A112-induced phosphorylation of VEGFR1 in U87MG human glioblastoma cells and phosphorylation of VEGFR2 in ZHE-483-2 GMEC [1]. |
| In vivo | Brolucizumab, administered intraperitoneally (15 mg/kg; i.p. 5 days per week for either 21 or 41 days), has been shown to slow the growth of mSLK-KSHV xenograft tumors [2]. Similarly, dosages ranging from 5-50 mg/kg given intraperitoneally once or twice daily for 28 days can delay tumor growth in the U87MG glioblastoma model [1]. Additionally, when administered intravenously (10 mg/kg; i.v.) to mice, brolucizumab exhibits a rapid elimination half-life of 5.4-7.8 minutes and a slow elimination half-life of 1.4-1.9 hours [2]. |
| Alias | RTH258, ESBA 1008, DLX1008 |
| Cas No. | 1531589-13-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Related Tags: buy Brolucizumab | purchase Brolucizumab | Brolucizumab cost | order Brolucizumab | Brolucizumab in vivo | Brolucizumab in vitro
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