Shopping Cart
- Remove All
![TargetMol](https://newstatic.targetmol.com/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | c-Met-IN-17 is a potent inhibitor of c-Met kinase, demonstrating an IC50 of 0.031 μM, and is applicable in anticancer research. [1] |
In vitro | c-Met-IN-17 (compound 29) demonstrated an IC50 value of 0.068 μM for the inhibition of D1228V c-MET enzymatic activity, as measured by the ADP-Glo assay [1]. |
In vivo | c-Met-IN-17, administered intravenously at a dose of 0.5 mg/kg to Wistar rats, demonstrated excellent bioavailability over a 24-hour period [1]. Pharmacokinetic analysis in Wistar rats [1] revealed the following parameters: clearance (Cl) at 60 mL/min/kg, steady-state volume of distribution (Vss_obs) at 4.6 L/kg, and a bioavailability of 100%. |
Molecular Weight | 374.37 |
Formula | C21H15FN4O2 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.