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Capmatinib xHCl
🥰Excellent
Catalog No. T8416Cas No. 1029714-89-3
Alias INCB28060, INC280, Capmatinib hydrochloride(free base)
Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).
Capmatinib xHCl
🥰Excellent
Purity: 99.24%
Catalog No. T8416Alias INCB28060, INC280, Capmatinib hydrochloride(free base)Cas No. 1029714-89-3
Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 2 mg | $50 | In Stock | |
| 5 mg | $71 | In Stock | |
| 10 mg | $107 | In Stock | |
| 25 mg | $191 | In Stock | |
| 50 mg | $288 | In Stock | |
| 100 mg | $432 | In Stock | |
| 500 mg | $987 | In Stock |
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CitedSelect Batch
Purity:99.24%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). |
| In vitro | Capmatinib hydrochloride blocks cell proliferation and migration or induces apoptosis in different types of cancer cells[1] |
| Alias | INCB28060, INC280, Capmatinib hydrochloride(free base) |
| Molecular Weight | 448.89 |
| Formula | C23H18ClFN6O |
| Cas No. | 1029714-89-3 |
| Smiles | Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4.48 mg/mL (9.99 mM)  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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