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Capmatinib 2HCl.H2O

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Purity:99.84%

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COA HPLC HNMR

Capmatinib 2HCl.H2O

Catalog No. T8825Cas No. 1865733-40-9

Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.

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Pack Size	Price	Availability
5 mg	$45	In Stock
10 mg	$63	In Stock
25 mg	$117	In Stock
50 mg	$186	In Stock
100 mg	$297	In Stock
500 mg	$622	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Product Introduction

Bioactivity

Description	Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.
In vitro	Capmatinib was found to be highly selective for MET over other kinases.?It was active against cancer models that are characterized by MET amplification, marked MET overexpression, MET exon 14 skipping mutations, or MET activation via expression of the ligand hepatocyte growth factor (HGF)[1].
In vivo	In cancer models where MET is the dominant oncogenic driver, anticancer activity could be further enhanced by combination treatments, for example, by the addition of apoptosis-inducing BH3 mimetics.?The combinations of capmatinib and other kinase inhibitors resulted in enhanced anticancer activity against models where MET activation co-occurred with other oncogenic drivers, for example EGFR activating mutations[1].
Alias	INCB28060 2HCl.H2O, INC-280 2HCl.H2O, NVP-INC280 2HCl.H2O

Chemical Properties

Molecular Weight	503.36
Formula	C23H21Cl2FN6O2
Cas No.	1865733-40-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (59.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9866 mL	9.9332 mL	19.8665 mL	99.3325 mL
5 mM	0.3973 mL	1.9866 mL	3.9733 mL	19.8665 mL
10 mM	0.1987 mL	0.9933 mL	1.9866 mL	9.9332 mL
20 mM	0.0993 mL	0.4967 mL	0.9933 mL	4.9666 mL
50 mM	0.0397 mL	0.1987 mL	0.3973 mL	1.9866 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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