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Ensartinib hydrochloride

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Purity:99.29%

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COA HPLC HNMR

Ensartinib hydrochloride

Catalog No. T22324Cas No. 2137030-98-7

Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.

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Pack Size	Price	Availability
1 mg	$60	In Stock
2 mg	$85	In Stock
5 mg	$147	In Stock
10 mg	$239	In Stock
25 mg	$488	In Stock
50 mg	$712	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Targets&IC50	TrkC:<1 nM, TPM3-TRKA:<1 nM, ALK (variants):<4 nM, GOPC-ROS1:<1 nM, ALK:<4 nM
In vitro	Ensartinib potently inhibits both wild-type ALK and all evaluated ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. Besides ALK, ensartinib also potently inhibits GOPC-ROS1, TPM3-TRKA, and TRKC with an IC50 of <1 nM, and inhibits EphA1, EphA2, EphB1 and c-MET with an IC50 of 1-10 nM[1].
Alias	Ensartinib dihydrochloride, X-396 dihydrochloride

Chemical Properties

Molecular Weight	634.36
Formula	C26H29Cl4FN6O3
Cas No.	2137030-98-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 33 mg/mL (52.02 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5764 mL	7.8820 mL	15.7639 mL	78.8196 mL
5 mM	0.3153 mL	1.5764 mL	3.1528 mL	15.7639 mL
10 mM	0.1576 mL	0.7882 mL	1.5764 mL	7.8820 mL
20 mM	0.0788 mL	0.3941 mL	0.7882 mL	3.9410 mL
50 mM	0.0315 mL	0.1576 mL	0.3153 mL	1.5764 mL

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